Abstract
A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology
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Fabaceae / chemistry*
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Humans
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Isoflavones / chemistry
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Isoflavones / isolation & purification
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Isoflavones / pharmacology
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Molecular Structure
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Nasopharyngeal Neoplasms
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Nuclear Magnetic Resonance, Biomolecular
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology
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Plant Stems / chemistry
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Plants, Medicinal / chemistry
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Pterocarpans*
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Structure-Activity Relationship
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Tumor Cells, Cultured / drug effects
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Tumor Cells, Cultured / enzymology
Substances
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Antineoplastic Agents, Phytogenic
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Benzopyrans
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Isoflavones
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Phenols
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Pterocarpans
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macharistol
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formononetin
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medicarpin
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inermin