Recognizing phosphatidylinositol 3-phosphate

S Misra; G J Miller; J H Hurley

doi:10.1016/s0092-8674(01)00594-3

Recognizing phosphatidylinositol 3-phosphate

Cell. 2001 Nov 30;107(5):559-62. doi: 10.1016/s0092-8674(01)00594-3.

Authors

S Misra¹, G J Miller, J H Hurley

Affiliation

¹ Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 11733055
DOI: 10.1016/s0092-8674(01)00594-3

Abstract

Phosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins by binding to FYVE and PX domains. New structures of these domains complexed with the phosphoinositide headgroup show how interactions with phosphate and hydroxyl groups differentiate this lipid from all others.

Publication types

Review

MeSH terms

Endosomes / metabolism*
Models, Molecular
Molecular Structure
Phosphatidylinositol Phosphates / chemistry
Phosphatidylinositol Phosphates / metabolism*
Protein Structure, Tertiary
Protein Transport / physiology
Signal Transduction / physiology
Zinc Fingers / physiology*

Substances

Phosphatidylinositol Phosphates
phosphatidylinositol 3-phosphate