Abstract
We investigated the effects of transforming growth factor-beta (TGF-beta) on biological behavior of a weakly malignant rat mammary carcinoma ER-1 cell line. TGF-beta enhanced the tumorigenic and metastatic capacity of ER-1 cells and their in vitro invasiveness to rat mesothelial and endothelial cell. Further cell biological analysis indicated that the increased invasive and metastatic capacity of ER-1 cells by TGF-beta was due to the increase in cell motility and adhesion to the mesothelial and endothelial cell monolayers. Thus, it is suggested that TGF-beta acts on ER-1 cells as a progression-enhancing factor which stimulates their adhesive and motile activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies / pharmacology
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Cell Adhesion / drug effects
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Cell Adhesion Molecules / genetics
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Cell Movement / drug effects
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Chemotaxis / drug effects
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DNA-Binding Proteins
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Dose-Response Relationship, Drug
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Female
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Hyaluronan Receptors / immunology
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Hyaluronic Acid / pharmacology
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Hyaluronoglucosaminidase / pharmacology
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Immediate-Early Proteins / genetics
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Kinetics
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Mammary Neoplasms, Experimental / pathology*
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Mice
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Neoplasm Invasiveness
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Neoplasm Metastasis / pathology*
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Nuclear Proteins / genetics
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Trans-Activators / genetics
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Transforming Growth Factor beta / pharmacology*
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Xenopus Proteins*
Substances
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Antibodies
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Cell Adhesion Molecules
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DNA-Binding Proteins
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Hyaluronan Receptors
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Immediate-Early Proteins
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MIER1 protein, Xenopus
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Nuclear Proteins
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Trans-Activators
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Transforming Growth Factor beta
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Xenopus Proteins
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Hyaluronic Acid
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Hyaluronoglucosaminidase