Abstract
A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry
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Amino Alcohols / chemistry
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Chromatography, High Pressure Liquid
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Enkephalin, Leucine / analogs & derivatives
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Enkephalin, Leucine / chemical synthesis
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Fluorenes / chemistry*
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Indicators and Reagents
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Molecular Mimicry
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Neurotensin / analogs & derivatives
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Neurotensin / chemical synthesis
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Oligopeptides / chemical synthesis*
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Polymers
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Urea / analogs & derivatives*
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Urea / chemical synthesis*
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Urea / chemistry
Substances
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Amino Acids
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Amino Alcohols
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Fluorenes
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Indicators and Reagents
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Oligopeptides
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Polymers
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Neurotensin
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Enkephalin, Leucine
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Urea
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1-(9-fluorenyl)methyl chloroformate