Lipase/palladium-catalyzed asymmetric transformations of ketoximes to optically active amines

Y K Choi; M J Kim; Y Ahn; M J Kim

doi:10.1021/ol0168622

Lipase/palladium-catalyzed asymmetric transformations of ketoximes to optically active amines

Org Lett. 2001 Dec 13;3(25):4099-101. doi: 10.1021/ol0168622.

Authors

Y K Choi¹, M J Kim, Y Ahn, M J Kim

Affiliation

¹ National Research Laboratory of Chirotechnology, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea.

PMID: 11735594
DOI: 10.1021/ol0168622

Abstract

[reaction: see text] Prochiral ketoximes were asymmetrically transformed to optically active amines in the acetylated forms by coupled lipase/palladium catalysis in the presence of an acyl donor under 1 atm of hydrogen.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry*
Enzymes, Immobilized
Fungal Proteins
Ketones / chemistry*
Lipase / chemistry
Lipase / metabolism*
Molecular Structure
Optical Rotation
Oximes / chemistry*
Palladium / chemistry*

Substances

Amines
Enzymes, Immobilized
Fungal Proteins
Ketones
Oximes
Palladium
Novozyme 435
Lipase
lipase B, Candida antarctica