Abstract
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the alpha-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
MeSH terms
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Animals
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COS Cells
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Drug Design
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Drug Evaluation, Preclinical
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Genes, Reporter
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Humans
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Phenylpropionates / chemical synthesis*
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Phenylpropionates / chemistry
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Phenylpropionates / pharmacology*
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Protein Isoforms / agonists
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Receptors, Cytoplasmic and Nuclear / agonists*
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Structure-Activity Relationship
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Transcription Factors / agonists*
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Transcriptional Activation / drug effects
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Transfection
Substances
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Phenylpropionates
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Protein Isoforms
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors