Severe axonal polyneuropathy after a FK506 overdosage in a lung transplant recipient

Y Boukriche; O Brugière; Y Castier; J Stocco; H Mal; M Fournier

doi:10.1097/00007890-200112150-00026

Severe axonal polyneuropathy after a FK506 overdosage in a lung transplant recipient

Transplantation. 2001 Dec 15;72(11):1849-50. doi: 10.1097/00007890-200112150-00026.

Authors

Y Boukriche¹, O Brugière, Y Castier, J Stocco, H Mal, M Fournier

Affiliation

¹ Department of Neurology, Beaujon Hospital, 100 Boulevard du Général Leclerc 92110, Clichy, France.

PMID: 11740402
DOI: 10.1097/00007890-200112150-00026

Abstract

FK506-induced polyneuropathies are rarely encountered. We report a case of axonal sensorimotor polyneuropathy in a lung transplant recipient that occurred during a FK506 overdosage. Onset was acute in the form of severe areflexic tetraparesis and resolution was observed after reduction of dosage. Because of increasing use of FK506 in solid organ transplantation, caution should be paid with FK506 dosage monitoring in cases of peripheral nervous system symptoms.

Publication types

Case Reports

MeSH terms

Dose-Response Relationship, Drug
Drug Overdose
Humans
Immunosuppressive Agents / administration & dosage
Immunosuppressive Agents / adverse effects*
Immunosuppressive Agents / therapeutic use
Lung Transplantation*
Male
Middle Aged
Polyneuropathies / chemically induced*
Polyneuropathies / physiopathology
Quadriplegia / chemically induced
Quadriplegia / physiopathology
Tacrolimus / administration & dosage
Tacrolimus / adverse effects*
Tacrolimus / therapeutic use

Substances

Immunosuppressive Agents
Tacrolimus