Abstract
The synthesis and spectral and magnetic characterization of VO(2+) complexes with Ibuprofen (2-(4-isobutylphenyl)propionic acid), Naproxen (6-methoxy-alpha-methyl-2-naphthalene acetic acid) and Tolmetin (1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid) were studied. The complexes [VO(Ibu)(2)] x 5CH(3)OH, [VO(Nap)(2)] x 5CH(3)OH and [VO(Tol)(2)] were obtained from methanolic solutions under nitrogen atmosphere. The biological activities of these complexes on the proliferation of two osteoblast-like cells in culture (MC3T3E1 and UMR106) were compared with that of the vanadyl(IV) cation. The complexes exhibited different effects depending on the concentration and the cellular type, while no effect was observed for their parent drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cell Division / drug effects
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Dose-Response Relationship, Drug
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Ibuprofen / chemistry
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Ibuprofen / pharmacology
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Mice
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Naproxen / chemistry
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Naproxen / pharmacology
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology
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Osteoblasts / drug effects*
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Rats
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Spectrum Analysis
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Tolmetin / chemistry
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Tolmetin / pharmacology
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Tumor Cells, Cultured / drug effects
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Vanadates / chemical synthesis*
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Vanadates / chemistry
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Vanadates / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Organometallic Compounds
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Vanadates
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Naproxen
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Tolmetin
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Ibuprofen