Abstract
FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / antagonists & inhibitors
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / pharmacology
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Antimalarials / pharmacology*
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Chloroquine / pharmacology
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Drug Combinations
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Drug Resistance / physiology
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Drug Synergism
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Iron Chelating Agents / pharmacology*
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Macrolides
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Norfloxacin / pharmacology
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects*
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Spermidine / analogs & derivatives*
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Spermidine / pharmacology*
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Tetracycline / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antimalarials
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Drug Combinations
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FR 160
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Iron Chelating Agents
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Macrolides
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Chloroquine
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Tetracycline
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Norfloxacin
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Spermidine