Abstract
The effectiveness of oral gatifloxacin was compared to that of standard parenteral antibiotic therapy (nafcillin) for the treatment of experimental methicillin-sensitive Staphylococcus aureus-induced osteomyelitis in a rabbit model. Gatifloxacin was as effective as nafcillin in clearing the infection. Therefore, oral gatifloxacin treatment of osteomyelitis may be an effective alternative to intravenous nafcillin treatment.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Administration, Oral
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Animals
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Anti-Infective Agents / therapeutic use*
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Disease Models, Animal
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Fluoroquinolones*
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Gatifloxacin
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Methicillin / pharmacology
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Nafcillin / therapeutic use
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Osteomyelitis / drug therapy*
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Penicillins / therapeutic use
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Rabbits
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Staphylococcus aureus / drug effects
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Treatment Outcome
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Penicillins
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Nafcillin
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Gatifloxacin
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Methicillin