Abstract
IL-10 has potent immunosuppressive properties, and IL-10-producing CD4+ Tr1 cells have been characterized as regulators of Th1-mediated immunity. In this study, using a s.c. model of glioma cell growth in mice, we demonstrate that CD4+, but not CD8+, T cells play a critical role in tumor rejection following vaccination with irradiated glioma cells. Surprisingly, glioma-specific CD4+ T cells produce IL-10 but neither IL-4 nor IFN-gamma, and glioma rejection is compromised in IL-10(-/-) hosts. Hence, our findings demonstrate that IL-10-producing CD4+ T cells can manifest antitumor functions and suggest that IL-10 may have proinflammatory effects in disease states.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Neoplasms / immunology*
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Brain Neoplasms / pathology
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Brain Neoplasms / therapy
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CD4-Positive T-Lymphocytes / immunology*
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Cell Division
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Cells, Cultured
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Cytokines / biosynthesis
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Cytokines / genetics
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Disease-Free Survival
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Glioma / immunology*
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Glioma / pathology
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Glioma / therapy
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Interleukin-10 / biosynthesis*
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Interleukin-10 / genetics
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Interleukin-10 / physiology*
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Kinetics
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Neoplasm Transplantation
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RNA, Messenger / biosynthesis
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Remission Induction
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T-Lymphocytes, Cytotoxic / immunology
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Tumor Cells, Cultured
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Up-Regulation
Substances
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Cytokines
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RNA, Messenger
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Interleukin-10