Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides

Neng Yang Shih; Margaret Albanese; John C Anthes; Nicholas I Carruthers; Cheryl A Grice; Ling Lin; Pietro Mangiaracina; Gregory A Reichard; John Schwerdt; Vera Seidl; Shing-Chung Wong; John J Piwinski

doi:10.1016/s0960-894x(01)00709-0

Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides

Bioorg Med Chem Lett. 2002 Jan 21;12(2):141-5. doi: 10.1016/s0960-894x(01)00709-0.

Authors

Neng Yang Shih¹, Margaret Albanese, John C Anthes, Nicholas I Carruthers, Cheryl A Grice, Ling Lin, Pietro Mangiaracina, Gregory A Reichard, John Schwerdt, Vera Seidl, Shing-Chung Wong, John J Piwinski

Affiliation

¹ Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033-1300, USA. [email protected]

PMID: 11755340
DOI: 10.1016/s0960-894x(01)00709-0

Abstract

The structural modification of the benzylic ether region of oxime 1 has resulted in the identification of several novel aryl amides as selective or dual NK(1)/NK(2) antagonists.

MeSH terms

Neurokinin-1 Receptor Antagonists*
Oximes / chemical synthesis*
Oximes / chemistry
Oximes / pharmacology*
Receptors, Neurokinin-2 / antagonists & inhibitors*
Structure-Activity Relationship

Substances

Neurokinin-1 Receptor Antagonists
Oximes
Receptors, Neurokinin-2