Efficacy of pulsed intravenous immunoglobulin therapy in mixed connective tissue disease

J Am Acad Dermatol. 2002 Jan;46(1):123-7. doi: 10.1067/mjd.2001.118539.

Abstract

We describe a 69-year-old patient with long-standing mixed connective tissue disease who suffered from severe skin eruptions that did not respond to various immunosuppressive regimens. Therapy with high-dose intravenous immunoglobulin was successful in controlling the patient's disease without major side effects. We think that this regimen-although expensive-might be an interesting therapeutic option in selected patients with mixed connective tissue disease that is refractory to other treatment modalities.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Facial Dermatoses / complications
  • Facial Dermatoses / drug therapy
  • Facial Dermatoses / pathology
  • Female
  • Hand Dermatoses / complications
  • Hand Dermatoses / drug therapy
  • Hand Dermatoses / pathology
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage
  • Immunoglobulins, Intravenous / therapeutic use*
  • Mixed Connective Tissue Disease / complications
  • Mixed Connective Tissue Disease / drug therapy*
  • Mixed Connective Tissue Disease / pathology
  • Pulse Therapy, Drug
  • Raynaud Disease / complications

Substances

  • Immunoglobulins, Intravenous