[A comparative clinical study of carboplatin solution and carboplatin powder]

Zhonghua Zhong Liu Za Zhi. 2001 Mar;23(2):170-2.
[Article in Chinese]

Abstract

Objective: To observe the efficacy and side effects of carboplatin solution in comparison with carboplatin powder.

Methods: A multicenter, open randomized controlled trial was carried out. A total of 121 patients with small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC) and breast cancer (BC) were randomized into carboplatin injection group (study group) and carboplatin powder group (control group), treated with CE, CIE and CAF protocol, respectively. The same drugs and dosage were used in the two groups.

Results: The response rate of the study group and the control group was 94% and 67% in SCLC (P > 0.05), 12% and 22% in NSCLC (P > 0.05) and 71.4% and 67% in BC (P > 0.05), respectively. The major side effects were myelosuppression and gastrointestinal reactions, the frequency and intensity of which were statistically not different in the 2 groups of patients.

Conclusion: Carboplatin solution is as effective as carboplatin powder for the treatment of cancer.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology
  • Carboplatin / adverse effects
  • Carboplatin / therapeutic use*
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Small Cell / drug therapy*
  • Carcinoma, Small Cell / pathology
  • Gastrointestinal Diseases / chemically induced
  • Humans
  • Leukopoiesis / drug effects
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / pathology
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Powders
  • Solutions
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Powders
  • Solutions
  • Carboplatin