Abstract
Nitric oxide (NO) has emerged as an important cytotoxic and cytostatic effector for a number of pathogens, including viruses, bacteria, fungi, and parasites. When the microbicidal effect of NO occurs, the NO-mediated S-nitrosylation of cysteine containing proteins (e.g., cysteine proteases) appears to be a common and widespread mechanism. This overview concerns parasitic cysteine proteases as NO targets, providing molecular bases for the parasiticidal effect of NO.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antiparasitic Agents / chemistry*
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Antiparasitic Agents / metabolism*
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Cysteine / metabolism
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Cysteine Endopeptidases / chemistry
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Cysteine Endopeptidases / metabolism
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Humans
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Models, Molecular
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Nitric Oxide / chemistry*
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Nitric Oxide / metabolism*
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Nitric Oxide Donors / metabolism
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Parasites / enzymology
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Parasites / metabolism*
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Protein Conformation
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Protozoan Proteins
Substances
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Antiparasitic Agents
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Nitric Oxide Donors
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Protozoan Proteins
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Nitric Oxide
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Cysteine Endopeptidases
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cruzipain
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Cysteine