Objective: To study the effect of ligustrazine on peritoneal transport in various dosages.
Methods: Forty SD rats received intraperitoneal injection of 25 ml 4.25% glucose dialysis solution (GDS) or GDS plus 40 mg/L ligustrazine (GDS-LL) or GDS plus 160 mg/L ligustrazine (GDS-HL) daily, for 45 days. Then a 4-hour dwell study was performed in each rat to evaluate the peritoneal transportation.
Results: The drainage volume at 4 hours was significantly lower in all the dialysis groups as compared to the control group, especially in the GDS-HL group. However, drainage volume was significantly higher in the GDS-LL group as compared to the GDS and GGS-HL groups. There were no significant differences in the peritoneal fluid absorption rate among the 3 dialysis groups. The fluid absorption rate and the direct lymphatic absorption rate were all significantly higher in the 3 dialysis groups as compared to the control group. In the GDS-LL group, the ratio of urea level in dialysis solution and in plasma (D/Purea) was not different in comparing with that in the GDS group, but the ratio of glucose concentration in dialysis solution and that in unused dialysis solution (D/D0), and urea clearance were significantly higher than those in the GDS group and the GDS-HL group. D/Purea increased in the GDS-HL group significantly.
Conclusion: Low dose of ligustrazine adding to the dialysis solution could reduce the peritoneal damage caused by the hypertonic dialysis solution, increase the ultrafiltration function and dialysis function of peritoneum. However, high dose of ligustrazine does not display any beneficial effect, it increases the permeability of peritoneum.