Hematopoietic system-specific antigens as targets for cellular immunotherapy of hematological malignancies

Tuna Mutis; Els Goulmy

doi:10.1053/shem.2002.29248

Hematopoietic system-specific antigens as targets for cellular immunotherapy of hematological malignancies

Semin Hematol. 2002 Jan;39(1):23-31. doi: 10.1053/shem.2002.29248.

Authors

Tuna Mutis¹, Els Goulmy

Affiliation

¹ Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 11799526
DOI: 10.1053/shem.2002.29248

Abstract

Allogeneic stem cell transplantation (SCT) is the treatment of choice for many hematological malignancies. Its curative graft-versus-leukemia (GvL) effect is mainly mediated by donor-derived alloreactive T cells. However, if the donor T cells are not selected for their reactivity against leukemic cells, the GvL effect is often associated with graft-versus-host disease (GvHD), a major complication of SCT. Here we summarize our current knowledge on leukemia-associated antigens and discuss strategies to apply minor and major histocompatibility antigens for cellular immunotherapy of hematological malignancies with a low risk of GvHD.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antigens, Neoplasm / immunology*
Combined Modality Therapy / methods
Hematologic Neoplasms / immunology
Hematologic Neoplasms / therapy*
Humans
Immunotherapy / methods*
Immunotherapy, Adoptive / methods

Substances

Antigens, Neoplasm