Abstract
To elucidate the evolution of SEN virus (SEN-V), serial sequences of chronically SEN-V-infected patients were analyzed. In the hypervariable regions, non-synonymous substitutions significantly predominated. This could be attributed to positive selection in evading immune surveillance of the hosts and to establish a persistent infection. On the basis of the sequences in the two open reading frames of SEN-V DNA, the rate of synonymous substitutions was 7.32 x 10(-4) per site per year. Since this rate is close to RNA viruses and higher than other DNA viruses, the SEN-V might be replicated by machinery with poor or no proofreading function.
MeSH terms
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Chronic Disease
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Circoviridae / genetics*
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Circoviridae / immunology
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Circoviridae Infections / blood
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Circoviridae Infections / complications
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Circoviridae Infections / immunology
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Circoviridae Infections / virology*
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Complementarity Determining Regions / genetics*
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DNA, Viral / blood
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DNA, Viral / genetics
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Hepatitis / complications
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Hepatitis C / complications
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Humans
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Immunologic Surveillance
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Molecular Sequence Data
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Open Reading Frames / genetics
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Phylogeny
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Polymerase Chain Reaction
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Regression Analysis
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Selection, Genetic*
Substances
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Complementarity Determining Regions
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DNA, Viral
Associated data
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GENBANK/AB062295
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GENBANK/AB062296
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GENBANK/AB062297
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GENBANK/AB072965
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GENBANK/AB072966
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GENBANK/AB072967
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GENBANK/AB072968
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GENBANK/AB072969