Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor?

Circulation. 2002 Jan 22;105(3):272-5.

Authors

Andrew R Marks¹, Steven Reiken, Steven O Marx

Affiliation

¹ Center for Molecular Cardiology, Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY, USA. [email protected]

PMID: 11804976

No abstract available

Publication types

Editorial

MeSH terms

Adrenergic beta-Antagonists / therapeutic use
Animals
Arrhythmias, Cardiac / etiology
Calcium / metabolism
Cyclic AMP-Dependent Protein Kinases / metabolism*
Disease Progression
Genetic Predisposition to Disease
Heart Failure / drug therapy
Heart Failure / etiology*
Heart Failure / metabolism
Humans
Models, Cardiovascular
Mutation
Myocardial Contraction
Myocardium / metabolism
Phosphorylation
Ryanodine Receptor Calcium Release Channel / metabolism*
Sarcoplasmic Reticulum / metabolism
Signal Transduction

Substances

Adrenergic beta-Antagonists
Ryanodine Receptor Calcium Release Channel
Cyclic AMP-Dependent Protein Kinases
Calcium