Abstract
As part of a study on antitumor agents from rainforest plants, four new clerodane diterpenes, bucidarasins A--D (1-4), were isolated from Bucida buceras. Their structures were elucidated from detailed 2D NMR analyses. Compounds 1-3 showed potent cytotoxicity against human tumor cell lines with IC(50) values of 0.5-1.9 microM. The potency was retained in drug resistant lines.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Chromatography, High Pressure Liquid
-
Diterpenes / chemical synthesis*
-
Diterpenes / chemistry*
-
Diterpenes / pharmacology*
-
Diterpenes, Clerodane*
-
Drug Resistance, Neoplasm
-
Drug Screening Assays, Antitumor
-
Humans
-
Magnetic Resonance Spectroscopy
-
Mass Spectrometry
-
Plant Extracts / chemistry
-
Plants, Medicinal / chemistry*
-
Spectrophotometry, Infrared
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents, Phytogenic
-
Diterpenes
-
Diterpenes, Clerodane
-
Plant Extracts
-
bucidarasin A
-
bucidarasin B
-
bucidarasin C