Abstract
The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
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Animals
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Anti-Asthmatic Agents / chemical synthesis*
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Anti-Asthmatic Agents / pharmacokinetics
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Anti-Asthmatic Agents / pharmacology*
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Binding Sites
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Cyclic Nucleotide Phosphodiesterases, Type 4
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Furans / chemical synthesis*
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Furans / pharmacokinetics
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Furans / pharmacology*
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Guinea Pigs
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Indicators and Reagents
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Phosphodiesterase Inhibitors / chemical synthesis*
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Phosphodiesterase Inhibitors / pharmacokinetics
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Phosphodiesterase Inhibitors / pharmacology*
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Pyridines / chemical synthesis*
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Pyridines / pharmacokinetics
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Pyridines / pharmacology*
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Rolipram / metabolism
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Structure-Activity Relationship
Substances
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Anti-Asthmatic Agents
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Furans
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Indicators and Reagents
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Phosphodiesterase Inhibitors
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Pyridines
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3',5'-Cyclic-AMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 4
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Rolipram