Abstract
A novel series of potent and specific MMP-2,3,9,13 inhibitors has been obtained by modulation on solid phase by alpha and aryl substitutions on 3-arylthio-N-hydroxy-propionamides starting from itaconic acid.
MeSH terms
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Amides / chemical synthesis*
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Amides / pharmacology
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cartilage, Articular / drug effects
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Cartilage, Articular / metabolism
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Combinatorial Chemistry Techniques*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Humans
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Inhibitory Concentration 50
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Matrix Metalloproteinase Inhibitors*
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Melanoma / drug therapy
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Mice
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Neoplasm Metastasis / drug therapy
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Proteoglycans / drug effects
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Proteoglycans / metabolism
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Rabbits
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Structure-Activity Relationship
Substances
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Amides
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Antineoplastic Agents
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Enzyme Inhibitors
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Matrix Metalloproteinase Inhibitors
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Proteoglycans
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propionamide