Concentration profile of mRNA of kinine B1 and B2 receptors in the evaluation of colon pathologies

Folia Histochem Cytobiol. 2001:39 Suppl 2:181-2.

Abstract

Colon pathologies involve the activation of a number of inflammation mediators: cytokines, prostanoids and kinines. The expression patterns of the genes associated with their activation may provide a very sensitive marker of the physiological condition of the cells. This paper demonstrates certain statistically significant differences (p = 0.008) between the expression patterns of kinine B1 and B2 receptor encoding genes for colitis ulcerosa and a control group. The ratio of kinine B1/B2 concentrations changes significantly, on the average from 1.3 for a tissue assessed as healthy to 6.6 for colitis ulcerosa.

MeSH terms

  • Colitis, Ulcerative / pathology*
  • Colitis, Ulcerative / physiopathology
  • Humans
  • Polymerase Chain Reaction
  • RNA, Messenger / analysis
  • Receptor, Bradykinin B1
  • Receptor, Bradykinin B2
  • Receptors, Bradykinin / genetics*
  • Taq Polymerase

Substances

  • RNA, Messenger
  • Receptor, Bradykinin B1
  • Receptor, Bradykinin B2
  • Receptors, Bradykinin
  • Taq Polymerase