Bone marrow necrosis and refractory HELLP syndrome in a patient with catastrophic antiphospholipid antibody syndrome

Jayashree Sinha; Iftikhar Chowdhry; Sarah Sedan; Peter Barland

Bone marrow necrosis and refractory HELLP syndrome in a patient with catastrophic antiphospholipid antibody syndrome

J Rheumatol. 2002 Jan;29(1):195-7.

Authors

Jayashree Sinha¹, Iftikhar Chowdhry, Sarah Sedan, Peter Barland

Affiliation

¹ Albert Einstein College of Medicine and White Plains Medical Center Bronx New York, USA.

PMID: 11824961

Abstract

We describe a 22-year-old woman who developed extensive and fatal bone marrow necrosis along with involvement of liver, lung, and central nervous system during pregnancy in the background of very high titers of antiphospholipid and anti-beta2 glycoprotein antibodies. This case illustrates a rarely recognized, potentially fatal complication of aPL in the setting of pregnancy.

Publication types

Case Reports

MeSH terms

Abortion, Induced
Adult
Antiphospholipid Syndrome / complications*
Antiphospholipid Syndrome / metabolism
Antiphospholipid Syndrome / physiopathology
Arterial Occlusive Diseases / etiology
Arterial Occlusive Diseases / pathology
Bone Marrow Diseases / etiology*
Bone Marrow Diseases / metabolism
Bone Marrow Diseases / physiopathology
Catastrophic Illness
Cerebral Infarction / etiology
Cerebral Infarction / pathology
Fatal Outcome
Female
HELLP Syndrome / etiology*
HELLP Syndrome / metabolism
HELLP Syndrome / physiopathology
Humans
Necrosis
Pregnancy