Abstract
A significant difference in blood-acetaldehyde concentration was observed between high alcohol-preference (HAP) rats and low alcohol-preference (LAP) rats, newly developed different alcohol preference lines. This difference of acetaldehyde accumulation may be due to cytosolic aldehyde dehydrogenase (ALDH1) polymorphism, which has been reported previously. As the doses of ethanol we employed are higher than that of voluntary drinking, there may be little direct relationship between acetaldehyde accumulation and alcohol preference. We suggest therefore that the ALDH1 polymorphism is associated with alcohol preference in HAP/LAP lines through some other unidentified mechanism.
MeSH terms
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Acetaldehyde / blood*
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Alcohol Drinking / genetics
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Alcoholism / blood
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Alcoholism / genetics*
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Aldehyde Dehydrogenase / genetics
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Aldehyde Dehydrogenase 1 Family
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Animals
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Central Nervous System Depressants / administration & dosage
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Central Nervous System Depressants / pharmacokinetics
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Disease Models, Animal
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Ethanol / administration & dosage
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Ethanol / blood
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Ethanol / pharmacokinetics*
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Food Preferences
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Isoenzymes / genetics
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Mice
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Rats
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Rats, Inbred Strains
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Rats, Wistar
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Retinal Dehydrogenase
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Selection, Genetic
Substances
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Central Nervous System Depressants
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Isoenzymes
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Ethanol
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Aldehyde Dehydrogenase 1 Family
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Aldehyde Dehydrogenase
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ALDH1A1 protein, mouse
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Aldh1a1 protein, rat
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Retinal Dehydrogenase
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Acetaldehyde