Abstract
From the New Zealand ascidian, Lissoclinum notti a new natural product, N2,N2,7-trimethylguanine (1) has been isolated. The structure of 1 was elucidated by analysis of spectroscopic data.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Bacillus subtilis / drug effects
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Breast Neoplasms
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CDC2 Protein Kinase / metabolism
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CDC28 Protein Kinase, S cerevisiae / metabolism
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Candida albicans / drug effects
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Cell Cycle / drug effects
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Escherichia coli / drug effects
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Female
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Guanine / analogs & derivatives
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Guanine / chemistry
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Guanine / isolation & purification*
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Guanine / pharmacology
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Inhibitory Concentration 50
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Leukemia P388
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Lung Neoplasms
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Mass Spectrometry
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Mice
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Molecular Structure
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Nervous System Neoplasms
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New Zealand
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RNA / physiology
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Spectrophotometry, Infrared
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Spectroscopy, Fourier Transform Infrared
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Trichophyton / drug effects
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Tumor Cells, Cultured / drug effects
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Urochordata / chemistry*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antineoplastic Agents
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N(2),N(2),7-trimethylguanine
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Guanine
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RNA
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CDC2 Protein Kinase
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CDC28 Protein Kinase, S cerevisiae