Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: Case report and review of the literature

Am J Hematol. 2002 Feb;69(2):127-31. doi: 10.1002/ajh.10023.

Abstract

Waldenström's macroglobulinemia is a low-grade lymphoma that produces monoclonal IgM. Central nervous system symptoms are frequent in Waldenström's macroglobulinemia, mostly associated with blood hyperviscosity. Nevertheless, central nervous system infiltration by malignant cells (Bing-Neel syndrome) has rarely been reported. We describe the case of a 72-year-old man with Waldenstrom's macroglobulinemia and central nervous system infiltration by malignant cells with tumor formation. All similar cases reported in the literature are reviewed and the different therapeutic approaches discussed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biopsy
  • Bone Marrow / pathology
  • Brain / pathology*
  • Cladribine / therapeutic use
  • Combined Modality Therapy
  • Cyclophosphamide / therapeutic use
  • Dizziness
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunoglobulin M / blood
  • Magnetic Resonance Imaging
  • Male
  • Muscle Weakness
  • Prednisone / therapeutic use
  • Stereotaxic Techniques
  • Waldenstrom Macroglobulinemia / diagnosis
  • Waldenstrom Macroglobulinemia / drug therapy
  • Waldenstrom Macroglobulinemia / pathology*
  • Waldenstrom Macroglobulinemia / radiotherapy
  • Waldenstrom Macroglobulinemia / therapy*

Substances

  • Glucocorticoids
  • Immunoglobulin M
  • Cladribine
  • Cyclophosphamide
  • Prednisone