Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus

Bioorg Med Chem. 2002 Apr;10(4):941-6. doi: 10.1016/s0968-0896(01)00347-9.

Abstract

The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by 1H and 13C NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Cell Division / drug effects
  • Cell Line
  • Crystallography, X-Ray
  • Cytomegalovirus / drug effects*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Pyridines / chemical synthesis
  • Pyridines / pharmacology*
  • Pyridines / toxicity
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Pyridines
  • imidazo(1,2-a)pyridine