Abstract
[reaction: see text] A new method for the solid-phase synthesis of cyanamides is described. The attachment of a secondary amine to solid support is accomplished using Merrifield resin. After functionalization, cleavage is readily achieved with cyanogen bromide to afford the desired cyanamide.
MeSH terms
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Catalysis
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Cyanogen Bromide
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Cysteine Proteinase Inhibitors / chemical synthesis*
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Cysteine Proteinase Inhibitors / pharmacology
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Indicators and Reagents
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Nitriles / chemical synthesis*
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Pyrrolidines / chemical synthesis*
Substances
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Cysteine Proteinase Inhibitors
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Indicators and Reagents
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Nitriles
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Pyrrolidines
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Cyanogen Bromide