Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture

Bioresour Technol. 2002 Mar;82(1):43-9. doi: 10.1016/s0960-8524(01)00149-3.

Abstract

Yarrowia lipolytica LGAM S(7)1 presented remarkable growth on industrial glycerol used as sole carbon substrate. Nitrogen-limited flask cultures were accompanied by restricted synthesis of reserve lipid, whilst amounts of citric acid were produced extracellularly. On the contrary, high amounts of reserve lipid (up to 3.5 g/l, 43% w/w of lipids in dry biomass) were produced in highly aerated continuous cultures. Lipid production was favoured at low specific dilution rates whilst fat-free material yield increased over the whole range of D (h(-1)). The maximum volumetric productivity obtained was 0.12 g lipid/1 h. Storage lipid composition did not present remarkable changes in the specific dilution rates tested. Oleate and linoleate were the dominant cellular fatty acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomass
  • Citric Acid / metabolism
  • Culture Media / metabolism
  • Glycerol / metabolism*
  • Kinetics
  • Linoleic Acid / biosynthesis
  • Linoleic Acid / metabolism
  • Lipid Metabolism
  • Lipids / biosynthesis*
  • Oleic Acid / biosynthesis
  • Oleic Acid / metabolism
  • Yarrowia / growth & development
  • Yarrowia / metabolism*

Substances

  • Culture Media
  • Lipids
  • Citric Acid
  • Oleic Acid
  • Linoleic Acid
  • Glycerol