Abstract
The immunogenicity and protective efficacy of overlapping regions of the protective antigen (PA) polypeptide, cloned and expressed as glutathione S-transferase fusion proteins, have been assessed. Results show that protection can be attributed to individual domains and imply that it is domain 4 which contains the dominant protective epitopes of PA.
MeSH terms
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Animals
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Anthrax / mortality
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Anthrax / prevention & control*
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Anthrax Vaccines / immunology*
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Antigens, Bacterial*
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Bacterial Toxins / immunology*
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Female
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Mice
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Peptide Fragments / immunology
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Protein Structure, Tertiary
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Vaccination*
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Vaccines, Synthetic / immunology
Substances
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Anthrax Vaccines
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Antigens, Bacterial
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Bacterial Toxins
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Peptide Fragments
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Vaccines, Synthetic
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anthrax toxin