Objective: To explore relationship between polymorphism of ACE gene and hypertension.
Methods: A cross-sectional study was conducted and PCR technique was used to analyze gene polymorphism.
Results: Genotypes DD, ID and II of ACE gene accounted for 13.0% and 9.7%, 50.9% and 48.4%, and 36.1% and 41.9%, respectively, in the normotensives and hypertensives. Frequencies of I and D alleles for ACE gene were 61.6% and 66.1%, and 38.4% and 33.9%, respectively, in the normotensives and hypertensives. There was no significant difference in distribution of II, ID and DD genotypes and I/D allele frequencies of ACE gene between the hypertensives and normotensives in male Yi people.
Conclusion: Association between polymorphism of ACE gene and hypertension was uncertain.