Abstract
Eradication of gastrointestinal colonization with vancomycin-resistant enterococci (VRE) using a combination of oral bacitracin and gentamicin was evaluated. Twenty-eight evaluable treated patients were matched with 28 control patients. After 3 months of follow-up, 5 patients (18%) in the treatment group versus 1 patient (4%) in the control group (P = .2) had negative results on stool cultures, with a similar frequency of VRE bacteremia (P = .8). The use of oral bacitracin plus gentamicin did not reduce VRE colonization or bacteremia.
MeSH terms
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Administration, Oral
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use*
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Bacitracin / administration & dosage
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Bacitracin / adverse effects
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Bacitracin / therapeutic use*
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Case-Control Studies
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Enterococcus faecium / drug effects*
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Female
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Gentamicins / administration & dosage
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Gentamicins / adverse effects
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Gentamicins / therapeutic use*
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Gram-Positive Bacterial Infections / drug therapy*
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Humans
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Male
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Middle Aged
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Treatment Failure
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Vancomycin Resistance*
Substances
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Anti-Bacterial Agents
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Gentamicins
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Bacitracin