Nerve cell markers in ossifying fibromyxoid tumour of soft parts

Indian J Pathol Microbiol. 2001 Apr;44(2):163-7.

Abstract

Reported herein are two benign ossifying fibromyxoid tumors (OFMTs) of the soft tissues in axilla and terminal phalanx respectively. Both cases on immunohistochemistry (IHC) showed reactivity for vimentin, S-100 protein and glial fibrillary acidic protein (GFAP) antibodies. In addition, a focal/diffuse strong positivity for neurofilament (NF) and neuron specific enolase (NSE) was observed. Electron microscopy in one instance revealed abundant intermediate filaments, primitive cell junctions and a focally present external lamina. In the light of nerve cell differentiation of these tumors and the similarity of IHC profile and EM features of OFMT to a poorly differentiated malignant peripheral nerve sheath tumor (MPNST); it is suggested that OFMT is a variably differentiated PNST rather than a simple Schwannian neoplasm as is believed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism
  • Glial Fibrillary Acidic Protein / metabolism
  • Humans
  • Male
  • Middle Aged
  • Nerve Sheath Neoplasms / diagnosis*
  • Nerve Sheath Neoplasms / metabolism
  • Nerve Sheath Neoplasms / pathology
  • Ossification, Heterotopic
  • Phosphopyruvate Hydratase / metabolism
  • S100 Proteins / metabolism
  • Soft Tissue Neoplasms / diagnosis*
  • Soft Tissue Neoplasms / metabolism
  • Soft Tissue Neoplasms / pathology
  • Vimentin / metabolism

Substances

  • Biomarkers, Tumor
  • Glial Fibrillary Acidic Protein
  • S100 Proteins
  • Vimentin
  • Phosphopyruvate Hydratase