Induction of p57(KIP2) expression by p73beta

Eva Balint; Andrew C Phillips; Serguei Kozlov; Colin L Stewart; Karen H Vousden

doi:10.1073/pnas.062491899

Induction of p57(KIP2) expression by p73beta

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3529-34. doi: 10.1073/pnas.062491899. Epub 2002 Mar 12.

Authors

Eva Balint¹, Andrew C Phillips, Serguei Kozlov, Colin L Stewart, Karen H Vousden

Affiliation

¹ Regulation of Cell Growth Laboratory, Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702-1201, USA.

Abstract

The p53-related protein p73 has many functions similar to that of p53 including the ability to induce cell-cycle arrest and apoptosis. Both p53 and p73 function as transcription factors, and p73 activates expression of many genes that also are regulated by p53. Despite their similarities, it is evident that p53 and p73 are not interchangeable functionally, with p73 playing a role in normal growth and development that is not shared by p53. In this paper we describe the ability of p73beta but not p53 to activate expression of the cyclin-dependent kinase inhibitor p57(KIP) and KvLQT1, two genes that are coregulated in an imprinted region of the genome. Our results suggest that p73 may regulate expression of genes through mechanisms that are not shared by p53, potentially explaining the different contributions of p53 and p73 to normal development.

MeSH terms

Animals
Blotting, Western
Cell Cycle Proteins*
Cell Line
Cyclin-Dependent Kinase Inhibitor p57
DNA-Binding Proteins / metabolism*
E2F Transcription Factors
Genes, Tumor Suppressor
Genomic Imprinting / genetics
Humans
KCNQ Potassium Channels
KCNQ1 Potassium Channel
Mice
Nuclear Proteins / biosynthesis*
Nuclear Proteins / genetics
Nuclear Proteins / metabolism*
Potassium Channels / genetics
Potassium Channels, Voltage-Gated*
RNA, Messenger / genetics
RNA, Messenger / metabolism
Transcription Factors / metabolism
Tumor Cells, Cultured
Tumor Protein p73
Tumor Suppressor Protein p53 / metabolism
Tumor Suppressor Proteins
Up-Regulation*

Substances

CDKN1C protein, human
Cdkn1c protein, mouse
Cell Cycle Proteins
Cyclin-Dependent Kinase Inhibitor p57
DNA-Binding Proteins
E2F Transcription Factors
KCNQ Potassium Channels
KCNQ1 Potassium Channel
KCNQ1 protein, human
Kcnq1 protein, mouse
Nuclear Proteins
Potassium Channels
Potassium Channels, Voltage-Gated
RNA, Messenger
TP73 protein, human
Transcription Factors
Trp73 protein, mouse
Tumor Protein p73
Tumor Suppressor Protein p53
Tumor Suppressor Proteins