Asymmetric catalysis of hetero-ene reactions with tridentate Schiff base chromium(III) complexes

J Am Chem Soc. 2002 Mar 27;124(12):2882-3. doi: 10.1021/ja025588j.

Abstract

Tridentate Schiff base chromium(III) complex 1 catalyzes the asymmetric hetero-ene reaction between aryl aldehydes and either 2-methoxypropene or 2-trimethylsilyloxypropene to provide a series of beta-hydroxyenol ether products in high yields and enantioselectivities. X-ray crystallographic analysis of a closely related chromium complex reveals a bridged, dimeric structure bearing aquo-bound six-coordinate Cr(III) centers. A mechanism is proposed wherein water dissociation is effected by means of a chemical desiccant (BaO or silyl enol ether), thereby revealing the site for aldehyde complexation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Benzaldehydes / chemistry
  • Benzyl Alcohols / chemical synthesis*
  • Catalysis
  • Chromium / chemistry*
  • Crystallography, X-Ray
  • Ethers / chemical synthesis*
  • Organometallic Compounds / chemistry*
  • Schiff Bases / chemistry*

Substances

  • Benzaldehydes
  • Benzyl Alcohols
  • Ethers
  • Organometallic Compounds
  • Schiff Bases
  • Chromium