Abstract
Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of Neolitsea acuminatissima. The structures of compounds 1-3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24-0.04 microg/mL. Compound 20 was marginally cytotoxic to Hep G2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzoquinones / chemistry
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Benzoquinones / isolation & purification
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Benzoquinones / pharmacology
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Carcinoma, Hepatocellular / chemically induced
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Drug Screening Assays, Antitumor
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Hepatitis B virus
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Humans
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Inhibitory Concentration 50
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification*
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Lauraceae / chemistry*
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Molecular Conformation
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Taiwan
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents, Phytogenic
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Benzoquinones
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Isoquinolines
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Sesquiterpenes
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neolitacumone A
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neolitacumone B
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neolitacumone C
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neolitacumonine
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2,6-dimethoxy-1,4-benzoquinone