Abstract
Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Anthracenes / chemistry
-
Anthracenes / isolation & purification*
-
Anthracenes / pharmacology
-
Anthraquinones / chemistry
-
Anthraquinones / isolation & purification*
-
Anthraquinones / pharmacology
-
Benzophenones / chemistry
-
Benzophenones / isolation & purification*
-
Benzophenones / pharmacology
-
Chromatography, High Pressure Liquid
-
Drug Screening Assays, Antitumor
-
Humans
-
Indonesia
-
KB Cells / drug effects
-
Leukemia P388
-
Mice
-
Mice, Inbred DBA
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Bark / chemistry
-
Plant Leaves / chemistry
-
Plant Stems / chemistry
-
Plants, Medicinal / chemistry*
-
Tumor Cells, Cultured / drug effects
-
Vitamin E / analogs & derivatives*
-
Vitamin E / chemistry
-
Vitamin E / isolation & purification
-
Vitamin E / pharmacology
-
Xanthenes / chemistry
-
Xanthenes / isolation & purification*
-
Xanthones*
Substances
-
2,4,6-trihydroxybenzophenone 4-O-geranyl ether
-
Anthracenes
-
Anthraquinones
-
Benzophenones
-
Xanthenes
-
Xanthones
-
cratoxyarborequinone A
-
cratoxyarborequinone B
-
vismione B
-
Vitamin E
-
tocotrienol, delta
-
xanthone