Abstract
A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-alpha (TNF-alpha) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzodioxoles
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Cell Line, Transformed / drug effects
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Dioxolanes / pharmacology
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Drug Screening Assays, Antitumor
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Inhibitory Concentration 50
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Lipopolysaccharides / administration & dosage
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Macrophage Activation
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Macrophages / drug effects*
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Mice
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Mice, Inbred Strains
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Nitric Oxide / analysis
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Spectrophotometry, Ultraviolet
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Taiwan
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Tumor Necrosis Factor-alpha / analysis*
Substances
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Antineoplastic Agents, Phytogenic
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Benzodioxoles
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Dioxolanes
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Glycosides
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Lignans
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Lipopolysaccharides
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Tumor Necrosis Factor-alpha
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justicidins
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procumbenoside A
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tuberculatin
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Nitric Oxide
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diphyllin