Abstract
Based on the 4-hydroxy-1-azabicyclo[3.1.0]hexane structure of azinomycin, a 3,4-epoxypiperidine structure was designed as a novel and simple alkylating molecular unit, and some 3,4-epoxypiperidine derivatives were found to show DNA-cleavage activity, the structural requirements for which were revealed.
MeSH terms
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Alkylating Agents / chemical synthesis
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Alkylating Agents / chemistry
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Alkylating Agents / pharmacology*
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DNA / drug effects*
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DNA / metabolism
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DNA Damage
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Drug Design
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Epoxy Compounds / chemical synthesis
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Epoxy Compounds / chemistry
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Epoxy Compounds / pharmacology
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Molecular Structure
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Piperidines / chemical synthesis
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Piperidines / chemistry
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Piperidines / pharmacology
Substances
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3,4-epoxypiperidine
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Alkylating Agents
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Epoxy Compounds
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Piperidines
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DNA