Establishment of a new cell line (TAYA) of clear cell adenocarcinoma of the ovary and its radiosensitivity

Oncology. 2002;62(2):180-4. doi: 10.1159/000048265.

Abstract

A new cell line (TAYA) was established from ascites of a patient with clear cell adenocarcinoma of the ovary, and the sensitivity of the cell line to various anticancer drugs and radiation was investigated. The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin >10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine >10,000, showing that the cells had a low sensitivity to these anticancer drugs. In contrast, the 50% growth inhibitory dose (ID50) of radiation was 1.8 Gy, showing that the cells were highly sensitive to radiation. Thus, radiotherapy may be effective for treatment of clear cell adenocarcinoma of the ovary.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Clear Cell* / drug therapy
  • Adenocarcinoma, Clear Cell* / genetics
  • Adenocarcinoma, Clear Cell* / pathology
  • Adenocarcinoma, Clear Cell* / radiotherapy
  • Adult
  • Chromosomes / genetics
  • Colorimetry
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Female
  • Genes, Tumor Suppressor
  • Humans
  • Kinetics
  • Mutation
  • Ovarian Neoplasms* / drug therapy
  • Ovarian Neoplasms* / genetics
  • Ovarian Neoplasms* / pathology
  • Ovarian Neoplasms* / radiotherapy
  • PTEN Phosphohydrolase
  • Phosphoric Monoester Hydrolases / genetics
  • Tumor Cells, Cultured* / radiation effects
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Proteins / genetics

Substances

  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human