Antispasmodic and antimicrobial diterpenic acids from Viguiera hypargyrea roots

Planta Med. 2002 Mar;68(3):281-3. doi: 10.1055/s-2002-23146.

Abstract

Two spasmolytic diterpene acids, ent-beyer-15-en-19-oic acid and ent-kaur-16-en-19-oic acid, have been isolated from the roots of Viguiera hypargyrea by bioassay-guided fractionation. Beyerenoic acid was also active against Staphylococcus aureus, Enterococcus feacalis and Candida albicans.

Publication types

  • Letter

MeSH terms

  • Animals
  • Anti-Bacterial Agents
  • Anti-Infective Agents / pharmacology*
  • Asteraceae*
  • Bacteria / drug effects*
  • Candida albicans / drug effects
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Dose-Response Relationship, Drug
  • Enterococcus faecalis / drug effects
  • Gastrointestinal Transit / drug effects
  • Guinea Pigs
  • Ileum / drug effects
  • Ileum / physiology
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Molecular Structure
  • Muscle Contraction / drug effects
  • Parasympatholytics / pharmacology*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Diterpenes
  • Parasympatholytics
  • Plant Extracts
  • beyerenoic acid
  • kaurenoic acid