Biosynthesis of hibarimicins. III. Structures of new hibarimicin-related metabolites produced by blocked mutants

J Antibiot (Tokyo). 2002 Jan;55(1):61-70. doi: 10.7164/antibiotics.55.61.

Abstract

Structures of metabolites produced by blocked mutants of Microbispora rosea subsp. hibaria TP-A0121, hibarimicin-producer, were determined by spectroscopic analysis. HMP-Y6 is the dimer of the west half of hibarimicin B, the aglycon of which is the genuine biosynthetic intermediate. HMP-P1 is the shunt product arising from the release of a methanol molecule from hibarimicinone. HMP-P4, the glycoside of HMP-P1, is glycosylated with two amicetoses and two digitoxoses same as hibarimicin B. HMP-M1, M2, M3 and M4 are shunt products derived from the monomeric undecaketide intermediates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / metabolism*
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Mutagenesis
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents