Abstract
Paradoxically, the pituitary-adrenal axis is not activated during sodium lactate-induced panic. We measured the response of another stress-sensitive hormone, prolactin, to standard lactate and placebo infusion in a double-blind randomised design in eight patients with panic disorder and eight matched normal controls. Prolactin release was significantly elevated (P < 0.05) in panickers compared with non-panickers, whereas ACTH secretion was not activated at all. This differential stress response needs further investigation.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adrenocorticotropic Hormone / blood*
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Adult
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Arousal / drug effects
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Arousal / physiology
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Double-Blind Method
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Female
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Humans
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Hypothalamo-Hypophyseal System / drug effects
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Hypothalamo-Hypophyseal System / physiopathology
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Male
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Panic / drug effects*
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Panic / physiology
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Panic Disorder / blood
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Panic Disorder / diagnosis*
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Pituitary-Adrenal System / drug effects
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Pituitary-Adrenal System / physiopathology
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Prolactin / blood*
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Sodium Lactate*
Substances
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Adrenocorticotropic Hormone
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Prolactin
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Sodium Lactate