A new integron carrying VIM-2 metallo-beta-lactamase gene cassette in a Serratia marcescens isolate

Jong Hwa Yum; Dongeun Yong; Kyungwon Lee; Hyon-Suk Kim; Yunsop Chong

doi:10.1016/s0732-8893(01)00352-2

A new integron carrying VIM-2 metallo-beta-lactamase gene cassette in a Serratia marcescens isolate

Diagn Microbiol Infect Dis. 2002 Mar;42(3):217-9. doi: 10.1016/s0732-8893(01)00352-2.

Authors

Jong Hwa Yum¹, Dongeun Yong, Kyungwon Lee, Hyon-Suk Kim, Yunsop Chong

Affiliation

¹ Department of Clinical Pathology, Research Institute of Bacterial Resistance, and Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, C.P.O. Box 8044, Seoul, Korea.

PMID: 11929695
DOI: 10.1016/s0732-8893(01)00352-2

Abstract

Serratia marcescens is an important nosocomial pathogen which is often resistant to multiple antimicrobial agents. An imipenem-resistant S. marcescens isolate from a urine specimen was found to carry a bla(VIM-2) gene cassette on a class 1 integron. This finding indicates that bla(VIM-2) is presently spreading even to Serratia spp. in Korea, which could compromise the usefulness of carbapenem in the treatment of multi-resistant Gram-negative bacilli infections. Clinical laboratory should be able to detect the VIM-2-producing isolates with even low carbapenem MIC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Drug Resistance, Bacterial / genetics*
Drug Resistance, Multiple, Bacterial
Humans
Korea
Microbial Sensitivity Tests
Mutagenesis, Insertional
Polymerase Chain Reaction
Recombination, Genetic / genetics*
Serratia marcescens / drug effects
Serratia marcescens / enzymology*
Serratia marcescens / genetics*
Serratia marcescens / isolation & purification
beta-Lactamases / genetics*
beta-Lactams

Substances

Anti-Bacterial Agents
beta-Lactams
VIM-1 metallo-beta-lactamase
beta-Lactamases