Abstract
Recent evidence suggests a link between the aberrant re-expression of cell cycle proteins in adult neurons of the Alzheimer's disease brain and the process of apoptotic degeneration. Here we will discuss this unexpected phenomenon as related to the mechanisms of beta-amyloid toxicity, and its significance for therapeutic possibilities.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / physiopathology*
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Amyloid beta-Peptides / metabolism
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Animals
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Apoptosis / physiology*
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Brain / metabolism*
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Cell Cycle Proteins / metabolism*
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Humans
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Mitogens / metabolism
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Neurochemistry / trends*
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Neurons / metabolism*
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Research
Substances
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Amyloid beta-Peptides
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Cell Cycle Proteins
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Mitogens