Abstract
Wild-type and J domain mutant simian virus 40 large T antigens alter the cell cycle and bud morphology of Saccharomyces cerevisiae. In contrast, yeast cells expressing mutant T antigen lacking the carboxy-terminal 150 aa exhibit normal morphology, indicating that this region of T antigen is required for cell cycle disruption.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigens, Polyomavirus Transforming / chemistry*
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Antigens, Polyomavirus Transforming / genetics
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Antigens, Polyomavirus Transforming / metabolism*
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Cell Cycle
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Saccharomyces cerevisiae / cytology*
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Saccharomyces cerevisiae / genetics
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Simian virus 40 / metabolism*
Substances
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Antigens, Polyomavirus Transforming