Abstract
A case of intraarticular synovial sarcoma arising in the knee verified by detection of the tumor-specific SYT-SSX fusion transcript is described. Although it is extremely rare, synovial sarcoma may occur entirely within a joint space. The molecular assay for detecting a tumor-specific chimeric gene is a valuable tool for diagnosis of soft tissue sarcoma, especially for diagnostically difficult cases and tumors in unusual locations.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Artificial Gene Fusion
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / isolation & purification*
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Chromosomes, Human, Pair 18
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Female
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Humans
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Knee Joint*
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Middle Aged
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Oncogene Proteins, Fusion / genetics
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Oncogene Proteins, Fusion / isolation & purification*
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Reverse Transcriptase Polymerase Chain Reaction
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Sarcoma, Synovial / diagnosis*
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Sarcoma, Synovial / genetics
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Sarcoma, Synovial / pathology
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Transcription, Genetic
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Translocation, Genetic
Substances
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Biomarkers, Tumor
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Oncogene Proteins, Fusion
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SYT-SSX fusion protein