Pathological changes due to intoxication of tetramethylenedisulphotetramine (TETS) were studied. The results showed that the signs of asphyxia were obvious, so were the congestion and edema of the brain. The spotty and focal hemorrhages in brain stems, multiple myolysis of papillary muscles and contractionbands necrosis of myocardium were observed occasionally. The main clinical symptom of intoxication was frequent clinic--tonic convulsions, which were similar to the grandma epilepsy. The poisoned died mainly in 3 hours. The general poisoning symptoms, LD50, toxicological mechanism and medicolegal expertise were also reviewed.