Abstract
To elucidate the effect of organophosphate pesticides on the expression of immediate early gene in skeletal muscle, the concentrations of c-fos mRNA and protein were measured by RT-PCR and western dot blot techniques. The result showed that c-fos mRNA and protein were significantly increased in skeletal muscle of rat after dosing with dimethoate. These results indicated that c-fos might act as transcription factor and regulate other gene expression during the early period of organophosphate intoxication.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dimethoate / toxicity*
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Genes, Immediate-Early
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Immediate-Early Proteins / biosynthesis
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Immediate-Early Proteins / genetics
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Insecticides / toxicity*
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Male
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Muscle, Skeletal / metabolism*
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Myasthenia Gravis / chemically induced
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Myasthenia Gravis / metabolism*
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Proto-Oncogene Proteins c-fos / biosynthesis*
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Proto-Oncogene Proteins c-fos / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Rats
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Rats, Wistar
Substances
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Immediate-Early Proteins
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Insecticides
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Proto-Oncogene Proteins c-fos
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RNA, Messenger
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Dimethoate